ORLANDO, Fla., Sept. 23, 2022 (GLOBE NEWSWIRE) — Today, Aviv Clinics highlights a brand new examine printed in Scientific Reports displaying an efficient remedy to heal broken mind tissue and relieve signs in youngsters experiencing persistent post-concussion syndrome (PPCS).
The examine, carried out by the Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center, is the primary trial wanting on the results of hyperbaric oxygen remedy (HBOT) for youngsters affected by PPCS and is without doubt one of the few sham-controlled research in PPCS that successfully research an answer for the situation. The examine means that HBOT improves cognitive, behavioral operate and high quality of life in pediatric sufferers affected by PPCS on the persistent stage, even years after their traumatic damage.
According to the Brain Injury Association of America, about half 1,000,000 youngsters affected by a concussion or traumatic mind damage are discharged from emergency departments within the U.S. every year. While the bulk recuperate in days to weeks following damage, as much as 25% endure signs for greater than three months after their damage and are thought of as PPCS. Children affected by PPCS expertise many signs, together with fatigue, anxiousness, irritability, complications, dizziness, and problem concentrating or processing phrases. The prognosis and remedy of those accidents are tremendously misunderstood and understudied, and present pointers for the remedy of concussion solely span the primary two weeks of signs. Leaving the situation untreated places the kid at a big drawback and instantly impacts their improvement into maturity.
“The diagnosis and treatment of post-concussion syndrome in children is a critical issue that physicians and researchers have struggled with, to the detriment of the children,” mentioned Dr. Shai Efrati, medical director of the Sagol Center for Hyperbaric Medicine and Research and Shamir Medical Center and Chair of Aviv Scientific’s Medical Advisory Board. “For the first time, we have demonstrated an effective treatment for pediatric PPCS, whether the injury occurred six months to 10 years ago. This discovery offers hope to the thousands of families watching their children suffer from unrelenting symptoms.”
The randomized, sham-control, double-blind trial evaluated the impact of HBOT on youngsters (ages 8-15) affected by PPCS from mild-moderate TBI occasions six months to 10 years prior. Participants have been injured from varied incidents, most ensuing from a fall or motorcar accident. Twenty-five youngsters have been randomized to obtain 60 day by day classes of HBOT or sham therapies. Recruitment was the primary problem of this trial – and learning pediatric concussions on the whole. Parents of injured youngsters have been reluctant for their little one to obtain a sham remedy (50% probability on randomization), thus resulting in many households declining to take part. Due to the significance of the subject and the necessity for solutions for youngsters with PPCS, researchers determined to proceed with the small examine group.
Participants have been divided into two teams: 15 obtained HBOT classes and ten obtained sham classes. Participants within the sham group obtained a protocol distinctive to this examine wherein they breathed regular air at 1.1 atmospheres absolute (ATA) for the primary 5 minutes, steadily reducing to 1 environment. While the individuals weren’t receiving any energetic remedy, the stress at first of the sham classes created the necessity to equalize stress, or “pop” their ears (which additionally happens throughout HBOT remedy), reaching a real placebo impact within the individuals.
The HBOT remedy protocol consisted of 60 day by day HBOT classes, 5 classes per week over a three-month interval, wherein individuals entered a multiplace HBOT chamber and breathed 100% oxygen by masks at 1.5 ATA for 60 minutes.
“We have accomplished many incredible firsts in this study, including a unique sham protocol which is the first of its kind in hyperbaric medicine. The protocol enables true masking and blinding of patients without any active treatment,” mentioned Dr. Amir Hadanny, Chief Researcher and Head of Global Clinical Operations at Aviv Clinics. “We performed an additional analysis to provide evidence that children were not able to tell whether they received hyperbaric oxygen or plain air. This true placebo effect paved the way for an effective study to better understand and offer a solution for PPCS in pediatrics.”
Upon completion of the examine, researchers discovered that individuals within the remedy group skilled a big improve in cognitive operate, together with the overall cognitive rating, reminiscence, and govt operate, following the HBOT remedy. Specific PPCS signs that noticed enchancment embody emotional rating, behavioral signs like hyperactivity, international govt composite rating, and planning and organizing rating. Perhaps most importantly, there was a optimistic change in mind construction of their MRIs on account of the HBOT, with microstructural adjustments occurring within the cortical areas related to PPCS signs and cognitive dysfunction, resulting in the numerous adjustments measured in reminiscence, verbal fluency, and govt operate. Participants within the management group didn’t enhance from baseline scores.
The identical remedy protocol carried out throughout this examine has been replicated by Aviv Clinics in Central Florida and Dubai. It is run beneath the identical strict protocols, with extra complete cognitive and bodily coaching assist for the assorted situations and signs addressed by Aviv together with concussion and TBI, lengthy COVID, stroke and extra.
The full examine is on the market right here. For extra on Aviv Clinics, go to aviv-clinics.com.
Aviv Clinics is the chief in treating age-related cognitive and practical decline and novel functions of recent protocols of hyperbaric oxygen remedy (HBOT) to maximise human efficiency. Based on an unique partnership with the world’s largest hyperbaric drugs and analysis facility, the Sagol Center at Shamir Medical Center in Israel, Aviv, is introducing a worldwide community of clinics delivering the efficient, evidence-based Aviv Medical Program. The two- to three-month routine designed to enhance cognitive and bodily decline relies on over a decade of analysis. More than 10,000 sufferers have been handled worldwide beneath the scientific management of Shai Efrati, M.D., Chair of Aviv Scientific’s Medical Advisory Board and Director of the Sagol Center.