Basel, Switzerland:
- Tenalisib (RP6530, selective twin PI3K d/γ inhibitor with extra SIK3 inhibitory exercise) confirmed encouraging outcomes with a medical profit fee (CBR) of 57.5% from an ongoing section II trial in sufferers with domestically superior or metastatic HR+/HER2- breast most cancers (mBC)
- RP12146, Rhizen’s subsequent technology PARP1/2 inhibitor concludes dose escalation section with a good security profile and has moved to the dose growth section in strong tumors
Rhizen Pharmaceuticals AG (Rhizen), a Swiss based mostly privately held, clinical-stage biopharmaceutical firm introduced right now that it’s presenting information from an ongoing Phase 2 trial of Tenalisib in domestically superior or metastatic breast most cancers and information from a concluded dose escalation section of RP12146 at ESMO 2022, Paris from Sept 9-13, 2022.
The multi-centre, randomized section II examine evaluating two doses of Tenalisib, a differentiated PI3K δ/γ inhibitor with extra SIK3 inhibitory exercise, has accomplished 24 weeks of remedy with a formidable Clinical Benefit Rate (CBR) of 57.5% and with no surprising security issues.Treatment with orally dosed Tenalisib was discovered to be efficient in a troublesome to deal with inhabitants the place majority of sufferers had visceral illness and a number of metastatic lesions. In addition, a lone TNBC affected person in the trial confirmed steady illness for greater than 6 months and is continuous on the examine.
Dose escalation of a Phase -I/Ib trial of RP12146, a subsequent technology PARP 1/2 inhibitor designed to beat the protection liabilities related to first technology PARP inhibitors, was efficiently accomplished and is enrolling at the RP2D dose for the growth section. RP12146 confirmed dose associated exposures with strong goal engagement and notable absence of haematological toxicities viz anaemia and cytopenia. The growth section at 400mg BID is at present in progress in genomically certified ovarian, breast and prostate most cancers sufferers with HRR mutations.
“We are pleased to report the clinical progress of our assets, particularly Tenalisib in a difficult to treat patient population of metastatic breast cancer showing sustained and beneficial disease control. In addition, our carefully designed next generation PARP1/2 inhibitor has successfully demonstrated the safety differential to first generation agents of this class and we are planning to rapidly progress into efficacy evaluations in various solid tumors as mono therapy and as rational combinations,” stated Swaroop Vakkalanka, Founder & CEO of Rhizen Pharmaceuticals AG.
- Tenalisib Poster Presentation schedule:
224P – Efficacy and security of Tenalisib, a PI3K delta/gamma and SIK3 inhibitor in sufferers with domestically superior or metastatic breast most cancers: Results from a section II examine
Presentation Number: 224P
Speakers: Tamta Makharadze (Tbilisi, Georgia)
Poster Session: Breast most cancers, metastatic
Date: Sat, 10.09.2022
Hall 4: Presentation time: (12:00-13:00 CEST)
- RP12146 Poster Presentation schedule:
483P – Pre-clinical and early medical evaluation of the protection and anti-tumor exercise of RP12146, a PARP1/2 inhibitor in strong tumors
Presentation Number: 483P
Speakers: Piotr Tomczak (Poznan, Poland)
Poster Session: Developmental therapeutics
Date: Mon, 12.09.2022
Hall 4: Presentation time: (12:00-13:00 CEST)
About Rhizen Pharmaceuticals AG:
Rhizen Pharmaceuticals is an progressive, clinical-stage biopharmaceutical firm centered on the invention and improvement of novel oncology & irritation therapeutics. Since its institution in 2008, Rhizen has created a various pipeline of proprietary drug candidates focusing on a number of cancers and immune related mobile pathways.
Rhizen is headquartered in Basel, Switzerland. For extra data, please go to https://www.rhizen.com/
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