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Extensive Curation of Asian-Specific Genetic Variants Enables Identification of Individuals at Elevated Risk of a Heart Attack
SAN FRANCISCO, CA, UNITED STATES, September 14, 2022 /EINPresswire.com/ — U.S. and Hong Kong-based Rainbow Genomics launches polygenic danger evaluation for coronary heart assault in Asian people utilizing entire genome sequencing knowledge. The check is especially helpful for confirming elevated lifetime danger for myocardial infarction in asymptomatic people.
This polygenic check depends on Asian-specific genetic variants. These genetic variants have been meticulously curated by the Rainbow scientific groups, utilizing public and non-published knowledge, and have been efficiently replicated in a number of worldwide research utilizing over 40,000 affected sufferers and matching controls over the past 15 years. These genetic variants are acceptable for danger evaluation of East Asians, together with Chinese, Japanese, and Koreans.
The genotypes are analyzed based mostly on entire genome sequencing check knowledge of sufferers, and the related danger calculations are carried out utilizing normal statistical instruments. The predictive energy is ample to establish a subgroup of the East Asian inhabitants that’s almost certainly to be in danger for a coronary heart assault. In addition, monogenic mutations related to abnormality of the cardiovascular system, that are decided by entire genome sequencing, will even be used. Based on each monogenic and polygenic variants, the resulted lifetime danger evaluation will present a further issue that’s complementary to conventional danger elements equivalent to low-density lipoprotein (LDL) degree, blood strain, age, and gender. This coronary heart assault danger evaluation report is now half of the findings reported in Rainbow Genomics Adult 6000(TM) and Adult 8000(TM) Whole Genome Sequencing assessments.
About the Rainbow Whole Genome Sequencing Test
The check gives 5 scientific reviews:
1. Personal Health Assessment
• Cancers
• Cardiovascular Disorders
• Endocrine System Abnormality together with Diabetes and Fatty Liver
• Sleep Disorders
• Hearing and Eye Disorders
• Skeletal and Bone Disorders
• Immune System Disorders
• Skin Abnormality
• Auto-inflammatory Disorders
• Behavioral Abnormality
• Neurological Disorders together with Dementia and Alzheimer Disease
2. Reproductive Health Assessment
• Male Infertility
• Female Infertility
3. Whole Genome Carrier Status
• Carrier Screening Analysis of Disorders Recommended by the American College of Obstetricians and Gynecologists and the American College of Medical Genetics
• Whole Genome Carrier Analysis – Mutations in 2500 genes related to recessive problems that may be handed on to the affected person’s kids
4. Common Disease Risk Assessment
• Common complicated illnesses equivalent to diabetes, coronary heart assault, and stroke are primarily precipitated by adjustments in a number of gene variants (polygenic dangers). However, these variants are extremely ethnic-specific. Polygenic danger evaluation for ethnic-specific teams equivalent to Asians is tough as a result of only a few publications utilizing Asian sufferers and wholesome controls with statistical significance can be found.
• Rainbow Genomics’ expert-curated polygenic variants are extremely ethnic-specific and are supported by large-scale genome extensive affiliation and replication research utilizing tens of hundreds of sufferers and controls collectively from Asia, U.S. and European nations.
5. Pharmacogenomic Assessment of 185 Medications to Improve Clinical Outcome
• For continual problems, reaching risk-reduction targets by way of enhancing medicine adherence is vital. Pharmacogenomic evaluation permits excessive therapeutic efficacy by way of minimization of drug negative effects, ensuing in higher remedy consequence.
About Rainbow Genomics
Rainbow Genomics (www.rainbowgenomics.com) is dedicated to offering clinically-validated genomic and proteomic testing to Asian, Caucasian, mixed-race, and native minority populations. The firm delivers excessive diagnostic success for physicians, enabling timely-treatment for sufferers that may profit from quick medical interventions.
Utilizing a multi-technology-platform strategy, together with proteomics, entire genome, entire exome, RNA, long-read, methylation, single cell and Sanger sequencing, high-resolution microarray testing, and high-density DNA array genotyping, and thru a number of worldwide collaborations, Rainbow Genomics delivers a diagnostic yield assembly or exceeding the very best requirements reported by main U.S. and European medical establishments.
All Rainbow Genomics assessments are carried out in CLIA-certified and CAP-accredited high-complexity scientific laboratories. Patient privateness is protected by Rainbow’s HIPAA-compliant scientific testing course of.
DANIEL SIU
Rainbow Genomics
+852 3481 0977
[email protected]
