ONE DRUG FOR ONE BUG: DEBIOPHARM TO DISCUSS THE POTENTIAL OF PATHOGEN-SPECIFIC ANTIBIOTICS AT THE 2022 WORLD AMR CONGRESS

• International well being authorities, such because the WHO and the CDC are warning of the rising hazard of bacterial infections immune to present antibiotics
• The 2022 World Anti-Microbial Resistance (AMR) Congress within the larger Washington D.C. space is serving as a discussion board to brazenly deal with the specter of AMR
• Debiopharm will be a part of the action-focused discussions round this silent pandemic in 3 panel discussions, presenting their microbiome-sparing FabI inhibitor class as a future software to struggle AMR

LAUSANNE, Switzerland, Sept. 8, 2022 /PRNewswire/ — Debiopharm, (www.debiopharm.com) a privately-owned, Swiss-based, biopharmaceutical firm dedicated to the event of novel class antibiotics, immediately revealed its involvement in three panel discussions on the World AMR Congress, going down in Fort Washington, Maryland, from September 7^th – 8^th. This convention provides pharmaceutical corporations, authorities, and coverage stakeholders from all all over the world the chance to fulfill, focus on and formulate initiatives to successfully sort out the rising risk of antimicrobial resistance. Debiopharm will current developments on its FabI inhibitor antibiotic class together with afabicin (Debio 1450), Debio 1453 and Debio 1454S, all of which have microbiome-sparing potential, a promising attribute for AMR prevention.

AMR is a number one explanation for demise and incapacity and represents a serious risk to human well being. Among the 1.27 million deaths¹ that happen globally because of antibiotic-resistant infections every year, greater than 35,000² happen in the United States and over 33,000³ happen in Europe. The financial burden of AMR can also be important⁴ in direct well being care and misplaced productiveness prices are attributable to antibiotic-resistant micro organism like Staphylococcus spp.

The WHO and the CDC have recognized such pathogens posing a risk to public well being and Debiopharm, one of many few non-public corporations nonetheless engaged within the growth of novel antibiotics, has directed its efforts towards concentrating on them. The World AMR summit provides an incredible alternative to governments, funds, associations, and passionate corporations like Debiopharm to affix forces in opposition to one of many prime world public threats going through humanity.

“We’re proud to unveil more on the role our novel class antibiotic, the FabI inhibitors, amongst key international stakeholders at the World AMR. We’re hoping that our collaboration with specialized organizations and lawmakers will trigger the much needed changes in the way we think about the unmet need for antibiotics as well as provide hope to people and health practitioners dealing with these seemingly insurmountable infections,” acknowledged Mohammed Benghezal, Global Project Lead in Anti-infectives, Debiopharm.

“Pathogen-specific antibiotic effect without harming the ‘good’ gut bacteria: it is the best of both worlds! As we research their efficacy and safety profile, this class of antibiotics could be like no other,” expressed Ricardo Chaves, Executive Medical Director, Debiopharm. “Now is the time to encourage the development of new antibiotic classes by establishing new business models that will assure future patients access to effective treatments that will knock out highly resistant bacterial infections and at the same time prevent AMR development.”

About afabicin

Afabicin (Debio 1450) is Debiopharm’s first-in-class FabI inhibitor in opposition to Staphylococcus spp., whose sub-class Methicillin-resistant Staphylococcus aureus (MRSA) is excessive on the WHO world precedence pathogen listing and deemed a “serious threat” by the CDC. Afabicin could be administered orally or IV and selectively targets Staphylococcus‘ important bacterial fatty acid biosynthesis. Promising outcomes have been obtained in a comparative double-blind Phase 2 trial with afabicin in acute bacterial pores and skin and pores and skin construction infections. Currently, a world Phase 2 trial in bone and joint infections is being carried out evaluating afabicin to plain antibiotics.

About Debio 1453 and Debio 1454S

Analogous to Afabicin, the preclinical compounds Debio 1453 and Debio 1454S are potential first-in-class pathogen-specific medicine concentrating on the important bacterial fatty acid biosynthesis. Debio 1453 could be administered orally or intramuscularly to deal with Neisseria gonorrhoeae infections whereas Debio 1454S is being developed for IV use in instances of hospital-acquired pneumonia and ventilator-associated pneumonia attributable to carbapenem-resistant Acinetobacter baumannii.

Debiopharm’s struggle in opposition to antimicrobial resistance 

Debiopharm, an innovation-focused, Swiss biopharmaceutical firm is among the few privately owned corporations growing novel class antibiotics to fight hard-to-treat infections. Through their distinctive partnership-based business mannequin, the corporate is advancing pathogen-specific antibiotics from early stage by means of section II medical analysis with afabicin, particularly concentrating on staphylococci, being probably the most clinically superior for the remedy of bone and joint infections. As a results of excessive selectivity, FabI inhibitors particularly goal chosen pathogens whereas preserving intestinal microbiota and meet all 4 WHO 2020 innovation standards: new chemical class, new goal, new mode of motion and no cross-resistance to different antibiotic lessons.

For extra info, please go to www.debiopharm.com

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Debiopharm Contact 

Dawn Haughton 

Communication Manager 

[email protected] 

Tel: +41 (0)21 321 01 11

References

^[1] Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: a scientific evaluation. Lancet. 2022;399(10325):629-655.

^[2] CDC Antibiotic resistance threats in the United States, 2019. https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf 

^[3] Cassini A, et al. Attributable deaths and disability-adjusted life-years attributable to infections with antibiotic-resistant micro organism within the EU and the European Economic Area in 2015: a population-level modelling evaluation. Lancet Infect Dis. 2019;19(1):56-66.

^[4] CDC Antibiotic resistance threats in the United States, 2013. https://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf 

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