VIENNA, Oct. 8, 2022 /PRNewswire/ — Eating a Mediterranean diet, wealthy in fibre, mono-unsaturated fatty acids and polyphenols, has been related to improved immunotherapy response rates and progression-free survival in advanced melanoma sufferers, a new study presented in the present day at UEG Week 2022 has discovered.
Experts anticipate that the diet will play an necessary function in the success of immunotherapy and trials are being expanded to research outcomes for various tumour varieties, together with digestive cancers.
A Mediterranean diet, containing mono-and polyunsaturated fat from olive oil, nuts and fish, polyphenols and fibre from greens, fruit, and wholegrains, was considerably related to an improved response to immunotherapy medication referred to as Immune Checkpoint Inhibitors (ICIs). ICIs, which have been extremely profitable in treating melanoma, work by blocking immune system checkpoints, which then pressure the physique’s personal T-cells to assault cancers.
The new multi-centre study by researchers from the UK and the Netherlands, recorded the dietary consumption of 91 sufferers with advanced melanoma, who had been handled with ICI medication and monitored their progress with common radiographic response check-ups.
As properly as having a big affiliation with total response fee, a Mediterranean diet was considerably related to progression-free survival at 12 months.
Laura Bolte, creator of the study and PhD candidate underneath supervision of Prof. Rinse Weersma from the University Medical Center Groningen, Netherlands, commented, “ICI has helped to revolutionise the treatment of different types of advanced cancers. Our study underlines the importance of dietary assessment in cancer patients starting ICI treatment and supports a role for dietary strategies to improve patient outcomes and survival.”
The study additionally discovered that consuming wholegrains and legumes lowered the chance of creating drug induced immune-related unintended effects, resembling colitis. In distinction, pink and processed meat was related to the next chance of immune-related unintended effects.
“The relationship of ICI response with diet and the gut microbiome opens a promising and exciting future to enhance treatment responses. Clinical trials investigating the effect of a high fibre diet, ketogenic diet and supplementation of omega-3 are underway. Since ICI therapy is being expanded to various tumour types, including digestive cancers, these studies could unlock treatment benefits for a large group of cancer patients in the future,” added Laura Bolte.
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