The study, based on 23 human clinical trials, indicates that such diets
contribute to a host of metabolic disorders
New Delhi, June 25, 2024: A groundbreaking study published in the Journal of
Metabolic Health reveals that low-salt diets can lead to systemic insulin resistance,
raising significant health concerns. The study, based on 23 human clinical trials,
indicates that such diets contribute to a host of metabolic disorders, including
diabetes, cardiovascular diseases (CVD), polycystic ovary syndrome (PCOS), Non-
alcoholic fatty liver disease (NAFLD) and obesity.
Renowned Consultant Interventional Cardiologist at Sattur Heart Care, Dr.
Ameet G Sattur, notes the cardiology perspective, explaining, “Low-salt diets are
indicated for some heart ailments and as a part of dietary restriction for patients
with hypertension. They can trigger insulin resistance, elevating the risk of
hypertension and increasing the risk of cardiovascular issues such as heart disease
and stroke. While sodium restriction may lower blood pressure in some, it often
leads to adverse metabolic outcomes. Twin Health’s tailored dietary plans consider
individual metabolic responses, offering a safer and more effective approach to
managing chronic conditions.”
The study highlights several mechanisms through which low-salt diets impact
insulin sensitivity, including activation of the sympathetic nervous system,
reduced skeletal muscle blood flow, and increased stress hormones like
noradrenaline and aldosterone. These changes can lead to severe metabolic
disruptions, making it essential to reassess the universal recommendation of low-salt
diets.
Dr. Maluk Mohammed, Co-Founder of Twin Health, adds, “Low-salt diets are
linked to significant metabolic disruptions, but our Whole-Body Digital Twin
technology can provide a solution. By analysing over 3,000 data points daily, we
deliver personalised nutrition recommendations that balance macro, micro, and biota
nutrients, ensuring better health outcomes.”
Focussing on nutritional perspective, Clinical Dietitian & Diabetes Educator Ms.
Kanikka Malhotra says, “Low-salt diets are often recommended for lowering blood
pressure (BP) but can have unintended consequences like worsening insulin
resistance. This resistance leads to elevated blood glucose levels, and weight gain.
Twin Health’s personalized nutrition approach, however, can help mitigate these
risks by providing balanced, individualized diet plans.”
Insulin resistance, the study explains, occurs when the body’s cells become less
responsive to insulin, leading to elevated blood glucose levels and a cascade of
metabolic issues. It affects glucose regulation, lipid metabolism, and even
mitochondrial function, contributing to conditions like non-alcoholic fatty liver
disease and polycystic ovary syndrome.
As India grapples with rising rates of chronic metabolic diseases, the findings
highlight the need for personalized nutrition strategies. Twin Health’s innovative
approach, leveraging advanced AI and digital twin technology, offers a promising
alternative to conventional dietary guidelines. By focusing on individual metabolic
needs, Twin Health aims to improve overall health outcomes and reduce the burden
of chronic diseases.
Consequences of Low-Salt Diet
- Glucose Regulation: Impaired insulin response leads to high blood sugar
and compensatory hyperinsulinemia. - Metabolic Consequences: Increased risk of type 2 diabetes,
cardiovascular diseases, obesity, dyslipidaemia, and non-alcoholic fatty liver
disease. - Inflammation & Oxidative Stress: Chronic low-grade inflammation
exacerbates metabolic syndrome. - Mitochondrial Dysfunction: Disrupted energy production and utilization.
- Muscle & Liver Health: Reduced glucose uptake in muscles and impaired
liver function. - Hormonal Imbalances: Affects hormones regulating appetite and insulin
sensitivity.
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